「手紙」 (tegami) means "letter." It's a written message sent to someone, typically by mail. You use it when referring to personal correspondence. Example: 友達に手紙を書きます。 (I will write a letter to my friend.)
「手紙」は、人に送るメッセージです。紙に書いて送ります。例:手紙を書きます。
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