「お酒」 (osake) means "alcohol," "liquor," or "sake." It refers to alcoholic beverages. While it can specifically mean Japanese sake, it's often used generally for all types of alcohol. 「お酒を飲みますか？」 (Do you drink alcohol?) is a common usage.

アルコールを含む飲み物全般を指します。日本酒のことも言います。