優先 is read ゆうせん, with both kanji using their on'yomi. ゆせん (missing long vowel) or ゆうぜん (voicing 先) are common errors. It means priority or preference, giving precedence to one thing over others.
「優先 (ゆうせん)」は優も先も音読みです。「ゆせん」(長音なし)や「ゆうぜん」(先の濁音化)は間違いです。他よりも先に扱うことを意味します。
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