Ogenki desu ka means "How are you?" or "Are you well?" This is a polite way to ask about someone's well-being. It's often used when greeting someone you haven't seen in a while, or to show concern. For example, after seeing an old friend, you might ask, "お元気ですか？最近どうですか？" (How are you? How have you been recently?).

相手(あいて)の体調(たいちょう)や様子(ようす)を尋ねる(たずねる)丁寧(ていねい)な表現(ひょうげん)です。久しぶり(ひさしぶり)に会う(あう)人(ひと)に使う(つかう)ます。「お元気(げんき)ですか？」