「お酒」 (osake) means "alcohol," "liquor," or "sake." It refers to alcoholic beverages. While it can specifically mean Japanese sake, it's often used generally for all types of alcohol. 「お酒を飲みますか？」 (Do you drink alcohol?) is a common usage.

アルコール(あるこーる)を含(ふく)む飲(の)み物(もの)全般(ぜんぱん)を指(さ)します。日本酒(にほんしゅ)のことも言(い)います。