💡 Detailed Explanation
The correct answer is 「を抜きにしては」 (o nuki ni shite wa), meaning 'without...' or 'if we exclude (something essential)'. It is followed by a negative sentence showing that the main outcome would be impossible. 「ぬきで」 and 「なしに」 are simpler forms but 「を抜きにしては」 is the standard N2 grammar pattern that precisely matches this formal rhetorical structure. 「を問わず」 means 'regardless of'.