💡 Detailed Explanation
The speaker, likely a superior, is politely assigning a task with the phrase '～ても差し支えないかな'. The best response is to accept the task willingly and positively. 'はい、ぜひやらせてください。' (Yes, I'd be glad to do it.) shows enthusiasm. 'いえ、とんでもないです。' (No, not at all.) can be used for humility, but here it could be misconstrued as refusing the task. 'はい、差し支えありません。' (Yes, there is no problem.) is socially awkward as it sounds like the subordinate is giving permission to their superior.