How to say "Not" in Japanese

When translating "not" into Japanese, you must choose carefully between 到底 and いっさい. In Japanese, 到底 (とうてい (tōtei)) is typically associated with "(not) possibly, (not) by any means, utterly" (Syllabus Level: N2) and represents This adverb is almost always used with negative verbs or expressions to emphasize the impossibility or extreme difficulty of something. It expresses that something cannot happen no matter what.. On the other hand, いっさい (いっさい (issai)) maps to "(not) at all, absolutely (not), entirely (without)" (Syllabus Level: N2) and represents Used with negative verbs to emphasize a complete lack or absence of something. Stronger than 全然. A literal translation of "not" can often sound unnatural to native Japanese speakers if mixed up!